Dr. John O. Trent Ph.D.
Departments of Medicine, Biochemistry and Molecular Biology, James Graham Brown Cancer Center
The concentration of most research projects is structure-based drug design. This involves a process of rationalization, prediction, and design using molecular modeling. In all projects there is a strong experimental component, which can include NMR or X-ray structural data, molecular biology, or biophysics. The research interests of the lab range from the design of small molecule DNA binders, DNA structure (duplex, triplex, and quadruplex), protein drug design, protein-DNA interactions, and protein-protein interactions.
Dr. Trent emphasizes the importance of teamwork and understanding multiple disciplines.
For more information about Dr. Trent visit www.browncancercenter.org.